Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell line (A549) |
| Expression Pattern | up-regulated |
| Function Description | The transfection efficiency was ~100%,and the knockdown efficiency of HOXA11 AS in NSCLC cell lines was >75%, as determined by a reverse transcription quantitative polymerase chain reaction.Following the knockdown of HOXA11-AS,miR-642b-3p was significantly downregulated in A549 NSCLC cells.The ROC curve revealed that the area under curve (AUC) of HOXA11-AS was 0.700 for patients with lung adenocarcinoma and 0.964 for patients with squamous cell carcinoma,which may gain a moderate or high diagnostic value of HOXA11-AS level in lung cancer. |
| Pubmed ID | 29616096 |
| Year | 2018 |
| Title | A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |