Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | serous ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | SOC tissues, cell lines (OVCAR3, SKOV3, A2780, OVCA433, OVCA429, and TOV112D) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11as expression in cancer tissue was 77-fold higher than that of noncancerous tissue. Higher HOXA11as expression was significantly correlated with histological grade and preoperative CA125. HOXA11as overexpression in SOC cells led to increased cell proliferation, invasion, and migration. Moreover, HOXA11as was associated with the expression of genes involved in cell invasion, migration, and epithelial-mesenchymal transition (EMT), including VEGF, MMP-9, B-catenin, E-cadherin, Snail, Twist, and Vimentin. |
| Pubmed ID | 27737536 |
| Year | 2016 |
| Title | Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for serous ovarian cancer | OMIM COSMIC |