Basic Information
| LncRNA/CircRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 |
| Ensemble | ENSG00000240990 |
| Refseq | NR_002795 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cancer |
| ICD-0-3 | C64.9 |
| Methods | qPCR, RIP, Dual luciferase reporter assay, Western blot, etc. |
| Sample | ccRCC tissues, cell lines (ACHN, 786-O, A498, OSRC-2, HK-2) |
| Expression Pattern | up-regulated |
| Function Description | Function assays showed that HOXA11-AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11-AS could act as a competing endogenous RNA (ceRNA) that repressed miR-146b-5p expression, which regulated its downstream target MMP16 in renal cancer. |
| Pubmed ID | 29953617 |
| Year | 2018 |
| Title | HOXA11-AS promotes the growth and invasion of renal cancer by sponging miR-146b-5p to upregulate MMP16 expression. |
External Links
| Links for HOXA11-AS | GenBank HGNC NONCODE |
| Links for renal cancer | OMIM COSMIC |