Basic Information
| LncRNA/CircRNA Name | HOXA-AS2 |
| Synonyms | homeobox A cluster antisense RNA2 |
| Region | GRCh38_7:27107777-27134302 |
| Ensemble | ENSG00000253552 |
| Refseq | NR_122069 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase Reporter Assay, RIP, Western blot |
| Sample | OS tissues,osteoblast cell line NHost and OS cell lines (U2OS and MG-63) |
| Expression Pattern | up-regulated |
| Function Description | HOXA-AS2 expression was increased in OS tissues and cells and associated with poor survival of patients. Knockdown of HOXA-AS2 inhibited cell viability, migration and invasion in OS cells.Interference of HOXA-AS2 attenuated U2OS xenograft tumor growth via upregulating miR-124-3p and downregulating E2F3. |
| Pubmed ID | 31853184 |
| Year | 2019 |
| Title | Knockdown of lncRNA HOXA-AS2 Inhibits Viability, Migration and Invasion of Osteosarcoma Cells by miR-124-3p/E2F3 |
External Links
| Links for HOXA-AS2 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |