Basic Information
| LncRNA/CircRNA Name | HOXA-AS2 |
| Synonyms | NA |
| Region | GRCh38_7:27107777-27134302 |
| Ensemble | ENSG00000253552 |
| Refseq | NR_122069 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot |
| Sample | SPCA1, A549, PC-9, H1975 and normal human bronchial epithelial cell (16HBE)., NSCLC tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | By comparing with the expression level in adjacent tissues, HOXA-AS2 expression was higher in NSCLC samples. Moreover, HOXA-AS2 knockdown inhibited invasion and migration of NSCLC cells and, conversely, HOXA-AS2 overexpression obtained the opposite results. In addition, the mRNA and protein expressions of IGF2 were downregulated via HOXA-AS2 knockdown. Besides, the expression of IGF2 was positively correlated to the expression of HOXA-AS2 in NSCLC tissues |
| Pubmed ID | 31210310 |
| Year | 2019 |
| Title | Long noncoding RNA HOXA-AS2 promotes cell migration and invasion via upregulating IGF-2 in non small cell lung cancer as an oncogene |
External Links
| Links for HOXA-AS2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |