Basic Information
| LncRNA/CircRNA Name | HOXA-AS2 |
| Synonyms | HOXA-AS2, HOXA3as |
| Region | GRCh38_7:27107777-27134302 |
| Ensemble | ENSG00000253552 |
| Refseq | NR_122069 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase report assay etc. |
| Sample | breast cancer tissues, cell lines (MCF-10A, MDA-MB-231, MDA-MB-453, and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | HOXA-AS2 was up-regulated in human breast cancer tissues and cell lines and associated with clinicopathological characteristics. HOXA-AS2 may be a potential prognostic and therapeutic target in breast cancer. HOXA-AS2 controls the expression of miR-520c-3p target genes, TGFBR2 and RELA, in breast cancer cells. |
| Pubmed ID | 28545023 |
| Year | 2017 |
| Title | Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge. |
External Links
| Links for HOXA-AS2 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |