Basic Information
| LncRNA/CircRNA Name | HOXA-AS3 |
| Synonyms | NA |
| Region | GRCh38_7:27129977-27155928 |
| Ensemble | ENSG00000254369 |
| Refseq | NR_038831 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | lung adenocarcinoma tissues, cell lines (A549) |
| Expression Pattern | up-regulated |
| Function Description | HOXA-AS3 was significantly upregulated in LAD tissues and A549 cells. After knockdown of HOXA-AS3, cell proliferation, migration, and invasion were inhibited. Xenografts derived from A549 cells transfected with shRNA/HOXA-AS3 had significantly lower tumor weights and smaller tumor volumes. We also demonstrated that HOXA-AS3 increased HOXA6 mRNA stability by forming an RNA duplex. In addition, HOXA6 promoted cell proliferation, migration, and invasion in vitro. Using a RNA pull-down assay, we found that HOXA-AS3 bonded with NF110, which regulated the cell localization of HOXA-AS3. Moreover, histone acetylation was involved in upregulation of HOXA-AS3. |
| Pubmed ID | 29899328 |
| Year | 2018 |
| Title | Increased Levels of the Long Noncoding RNA, HOXA-AS3, Promote Proliferation of A549 Cells |
External Links
| Links for HOXA-AS3 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |