Basic Information
| LncRNA/CircRNA Name | HOXB-AS3 |
| Synonyms | HOXA6as |
| Region | GRCh38_17:48549630-48606414 |
| Ensemble | ENSG00000233101 |
| Refseq | NR_033201 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RIP, Western blot, other |
| Sample | liver cancer tissues and cell lines(HepG, PLC, Hep3B, LM3) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOXB-AS3 in patients in stage III and IV was significantly higher than that in stage I and II. Inhibition of HOXB-AS3 expression in liver cancer cells including Hep3B and LM3 could promote cell proliferation, inhibit cell apoptosis and induce cell cycle arrest in the G0/G1 phase. The results of RIP and ChIP experiments showed that HOXB-AS3 inhibited the expression of p53 by binding to DNMT1, and overexpression of p53 in Hep3B cells could partially reverse the changes in cell proliferation and apoptosis induced by HOXB-AS3. |
| Pubmed ID | 30402841 |
| Year | 2018 |
| Title | lncRNA HOXB-AS3 promotes hepatoma by inhibiting p53 expression. |
External Links
| Links for HOXB-AS3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |