Basic Information
| LncRNA/CircRNA Name | HOXC-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:53999022-54000010 |
| Ensemble | ENSG00000250451 |
| Refseq | NR_047504 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | gastric cancer tissues,cell line (HFE145,AGS, MKN45, MKN28,HGC-27) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOXC-AS1 expression is upregulated in GC cells, decrease of lncRNA HOXC-AS1 inhibited cell viability. The binding was validated by RNA pull-down. Additionally, inhibition of eIF4AIII induced increase of lncRNA HOXC-AS1, thus promoting the cell proliferation and EMT process but deterring apoptosis of gastric cancer cells. Wnt/?-catenin signaling was impeded by HOXC-AS1 inhibition but restored by suppressed eIF4AIII. |
| Pubmed ID | 32307743 |
| Year | 2020 |
| Title | lncRNA HOXC-AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/?-Catenin signaling. |
External Links
| Links for HOXC-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |