Basic Information
| LncRNA/CircRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 |
| Ensemble | ENSG00000224189 |
| Refseq | NR_033979 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Dual luciferase reporter assay, etc. |
| Sample | cervical cancer tissues, cell lines (CaSki, HeLa) |
| Expression Pattern | up-regulated |
| Function Description | downregulation of HOXD-AS1 suppressed chemoresistance of cisplatin-resistant CC cells. we confirmed that HOXD-AS1 can act as a ceRNA to upregulate ZEB1 through miR-130a-3p. HOXD-AS1 enhanced chemoresistance of cisplatin-resistant CC cells through modulating miR-130a-3p/ZEB1 axis |
| Pubmed ID | 29896986 |
| Year | 2018 |
| Title | HOXD-AS1 exerts oncogenic functions and promotes chemoresistance in cisplatin-resistant cervical cancer cells. |
External Links
| Links for HOXD-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |