Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | Highly upregulated in liver cancer |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR |
| Sample | breast cancer samples,Breast cancer cell lines: MCF-7, ZR-75-1, BT-20, MDA-MB-231 and one normal breast cell line: MCF-10A |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HULC was overexpressed in breast cancer tissues and cell lines compared to normal healthy breast tissues and normal breast cell line. Moreover, the high expression of HULC was associated with metastasis and malignancy of breast cancers.HULC regulates the expression of LYPD1 through sponging miR-6754-5p. Moreover, overexpression of LYPD1 can rescue the migration and invasion abilities of breast cancer cells decreased by knockdown of HULC or overexpression of miR-6754-5p. |
| Pubmed ID | 31824174 |
| Year | 2019 |
| Title | Long Non-Coding RNA HULC Promotes the Development of Breast Cancer Through Regulating LYPD1 Expression by Sponging miR-6754-5p |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |