Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung squamous cell carcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, other |
| Sample | LSCC tissues and cell lines (H520, SK-MES-1) |
| Expression Pattern | down-regulated |
| Function Description | Significantly decreased level of lncRNA HULC was observed in LSCC samples compared with adjacent tissues. Besides, the expression of lncRNA HULC was negatively associated with protein tyrosine phosphatase receptor type O (PTPRO) in LSCC. Moreover, lncRNA HULC could promote the proliferation of LSCC cells by downregulating the expression PTPRO dependent on the phosphorylation and activation of nuclear factor-?B (NF-?B). The present study firstly shows strong evidence supporting a critical role of lncRNA HULC in promoting LSCC by regulating PTPRO/NF-?B signaling pathway, which provides new promising biomarkers for LSCC. |
| Pubmed ID | 31448453 |
| Year | 2019 |
| Title | LncRNA HULC Promotes Lung Squamous Cell Carcinoma by Regulating PTPRO via NF-?B |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for lung squamous cell carcinoma | OMIM COSMIC |