Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin,Adriamycin,5-FU | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, drugs sensitivity |
| Sample | Plasma, gastric adenocarcinoma cell lines (MGC-803 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | HULC was highly expressed in the plasma and tissues of the GC patients compared with controls, with HULC high expression indicating lower survival rate. HULC knockdown enhanced cisplatin-induced apoptosis in GC cells.We observed that HULC knockdown in both MGC-803 and MKN-45 cells significantly decreased the IC50 values of CDDP, ADR, and 5-FU |
| Pubmed ID | 28356873 |
| Year | 2016 |
| Title | Silencing of LncRNA HULC Enhances Chemotherapy Induced Apoptosis in Human Gastric Cancer |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |