Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | cell lines (MG63, hFOB1.19, OS-732) |
| Expression Pattern | up-regulated |
| Function Description | Suppression of HULC in osteosarcoma cells inhibited cell viability,migration,invasion, and promoted apoptosis. HULC functioned as an endogenous sponge for miR-122,and its silence functioned through upregulating miR-122.Furthermore,overexpression of miR-122 inactivated PI3K/AKT, JAK/STAT, and Notch pathways by downregulation of HNF4G. high levels of HULC were associated with low survival rates in osteosarcoma patients. |
| Pubmed ID | 28688193 |
| Year | 2017 |
| Title | Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |