Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (PC3, LNCaP, DU145, RWPE-1) |
| Expression Pattern | down-regulated |
| Function Description | In PC3 and LNCaP cells under irradiation, survival rate and cell cycle were decreased and apoptosis was increased by HULC knockdown. HULC knockdown arrested PC3 cells at G0/G1 phase.DU-145 was sensitive to irradiation, and resistance to irradiation of DU-145 cells was enhanced by HULC overexpression.HULC knockdown enhanced the sensitivity of PC3 xenografts to irradiation.HULC knockdown improved sensitivity of PCa cells to irradiation both in vivo and in vitro. HULC suppressed Beclin-1 phosphorylation, thereby reduced autophagy, involving the mTOR pathway.the irradiationinduced decrease of survival rate in PCa cells and alteration of survival rate induced by irradiation were further augmented by HULC knockdown but reduced by HULC overexpression. |
| Pubmed ID | 29694502 |
| Year | 2018 |
| Title | LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |