Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | hepatocarcinoma cell lines (HepG2, Huh7, HepG2.2.15 ), hepatocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Interestingly, we also observed that HULC could up-regulate HMGA2 in HCC cells. Mechanistically, we found that the microRNA-186 inhibited HMGA2 expression by targeting the 3'-untranslated region (3'-UTR) of HMGA2 mRNA. Strikingly, HULC acted as a competing noncoding RNA to sequester miR-186 and thereby relieved miR-186-mediated HMGA2 repression. Previously, our group reported that HULC could be up-regulated by hepatitis B virus X protein (HBx) through transcription factor CREB. HULC interacted with the 5-untranslated region (5-UTR) of CLOCK mRNA via complementary base pairing, resulting in the elevation of CLOCK expression. |
| Pubmed ID | 28765279 |
| Year | 2017 |
| Title | The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |