Basic Information
| LncRNA/CircRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 |
| Ensemble | ENSG00000251164 |
| Refseq | NR_004855 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (HepG2, Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | HULC promoted the growth of HCC cells through elevating COX-2 protein. knockdown of USP22 or COX-2 attenuated HULC-mediated abnormal growth of HCC cells.HULC promoted the survival of HepG2 and Hep3B cells in a dosedependent manner.We previous revealed that three miRNAs (miR-6825e5p, miR-6845e5p and miR-6886e3p) were involved in HULC mediated USP22 and Sirt1 upregulation |
| Pubmed ID | 28634076 |
| Year | 2017 |
| Title | lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein. |
External Links
| Links for HULC | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |