Basic Information
| LncRNA/CircRNA Name | IDH1-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:208255247-208256181 |
| Ensemble | ENSG00000231908 |
| Refseq | NR_046452 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | PCa and corresponding para-cancerous tissues ,human prostate epithelial cell line (RWPE-1) and human PCa cell lines (PC-3, DU145, VCaP, and LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | At first, the expression of IDH1-AS1 was identified to be upregulated in PCa samples and cell lines.PAX5 is the transcriptional activator of IDH1-AS1. Functionally, silencing of IDH1-AS1 inhibited cell proliferation and induced cell apoptosis both in vitro and in vivo. IDH1-AS1 can affect PCa cell autophagy by upregulating ATG5 expression. IDH1-AS1 posttranscriptionally regulated ATG5 expression by enhancing the mRNA stability of ATG5 or upregulating ATG5 by sequestering miR-216b-5p. IDH1-AS1 promoted proliferation and apoptosis in PCa via ATG5-induced autophagy. |
| Pubmed ID | 31570703 |
| Year | 2019 |
| Title | PAX5-induced Upregulation of IDH1-AS1 Promotes Tumor Growth in Prostate Cancer by Regulating ATG5-mediated Autophagy |
External Links
| Links for IDH1-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |