Basic Information
| LncRNA/CircRNA Name | IGFBP4-1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi, etc. |
| Sample | Liver Cancer cell lines (PC9, A549, GLiver Cancer -82, L78) |
| Expression Pattern | down-regulated |
| Function Description | Here, we conducted bioinformatics analysis and found insulin-like growth factor binding protein 4-1 (IGFBP4-1) as a new candidate lncRNA located in the upstream region of IGFBP4 gene.In cancer, abnormal expression and mutations of lncRNAs as important regulators can contribute to tumor development and progression through pathophysiological activities such as cell growth, apoptosis, invasion, and metastasis [4, 5, 6, 7, 8]. |
| Pubmed ID | 28946875 |
| Year | 2017 |
| Title | Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression. |
External Links
| Links for IGFBP4-1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |