Basic Information
| LncRNA/CircRNA Name | IGFL2-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:46189166-46203083 |
| Ensemble | ENSG00000268621 |
| Refseq | NR_135234 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR, Western blot analysis, Luciferase reporter assay |
| Sample | GC tissues,GC cell lines, SGC-7901, BGC-823, and AGS,normal gastric epithelium cell line (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | IGFL2-AS1 was highly expressed in GC tissues and cell lines. Knockdown of IGFL2-AS1 suppressed GC cell proliferation, migration, and invasion in vitro. Furthermore, we identified that IGFL2-AS1 exerted its function as a molecular sponge of miR-802. |
| Pubmed ID | 31943339 |
| Year | 2020 |
| Title | LncRNA IGFL2-AS1 Functions as a ceRNA in Regulating ARPP19 Through Competitive Binding to miR-802 in Gastric Cancer |
External Links
| Links for IGFL2-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |