Detail

Basic Information

LncRNA/CircRNA Name	ANRIL
Synonyms	NA
Region	GRCh38_9:21994778-22121097
Ensemble	ENSG00000240498
Refseq	NR_003529

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug	Cisplatin
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	osteosarcoma
ICD-0-3	NA
Methods	qPCR, Luciferase reporter assay, Western blot
Sample	osteosarcoma cell lines
Expression Pattern	differential expression
Function Description	In this study, ANRIL shRNA was used to knock down its endogenous expression in U2-OS and Saos-2 osteosarcoma cell lines. Our data showed that ANRIL-silenced cells were more sensitive to cisplatin: apoptotic ratio was increased and cleaved caspase-3 level was upregulated. Furthermore, the expression level of miR-125a-5p, a microRNA that can bind to ANRIL, was elevated in ANRIL-silenced cells.
Pubmed ID	30777616
Year	2019
Title	Effect of lncRNA ANRIL knockdown on proliferation and cisplatin chemoresistance of osteosarcoma cells in vitro.

External Links

Links for ANRIL	GenBank HGNC NONCODE
Links for osteosarcoma	OMIM COSMIC