Basic Information
| LncRNA/CircRNA Name | IRAIN |
| Synonyms | IRAIN, IGF1R-AS |
| Region | GRCh38_15:98645863-98651221 |
| Ensemble | NA |
| Refseq | NR_126453 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Northern blot, ChIP, in vitro knockdown etc. |
| Sample | blood, cell lines (K562, KG-1, KG-1a, HL60, TF1) |
| Expression Pattern | down-regulated |
| Function Description | We demonstrate that this lncRNA interacts with chromatin DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop. In addition, IRAIN was downregulated both in leukemia cell lines and in blood obtained from high-risk AML patients. Activating the IGF1R gene, lead to growth advantage and tumor progression. |
| Pubmed ID | 25092925 |
| Year | 2014 |
| Title | A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies. |
External Links
| Links for IRAIN | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |