Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | Antisense noncoding RNA in the INK4 locus |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | Dual luciferase reporter assay, qRT-PCR, Western blotting |
| Sample | LSCC and the adjacent normal tissues,LSCC cell lines AMC-HN-8 and SNU-899 |
| Expression Pattern | up-regulated |
| Function Description | ANRIL was up-regulated while miR-181a was down-regulated in LSCC tissues.ANRIL could directly sponge miR-181a to counteract its suppression on Snai2, serving as a positive regulator of Snai2. Either knockdown of ANRIL or overexpression of miR-181a significantly inhibited the proliferation, clonogenicity, invasion, migration and epithelial mesenchymal transformation (EMT), as well as promoted the apoptosis of LSCC cells, and knockdown of miR-181a reversed the effects. |
| Pubmed ID | 31667207 |
| Year | 2019 |
| Title | Long Non-Coding RNA ANRIL Promotes Proliferation, Clonogenicity, Invasion and Migration of Laryngeal Squamous Cell Carcinoma by Regulating miR-181a/Snai2 Axis |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |