Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1 opposite strand/antisense transcript 1 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Luciferase reporter assay |
| Sample | OC cells (SKOV3, OVCAR3) and normal ovarian epithelial cell line (IOSE80) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 was elevated expression in OC cells and indicated poorer overall survival of OC patients. Besides, we found KCNQ1OT1 could promote OC cell proliferation and migration in vitro.KCNQ1OT1 could regulate OC development via MIR-142-5p/CAPN10 axis. |
| Pubmed ID | 31909901 |
| Year | 2020 |
| Title | KCNQ1OT1 Promotes Ovarian Cancer Progression via Modulating MIR-142-5p/CAPN10 Axis |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |