Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Adriamycin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Dual luciferase reporter assay, RIP |
| Sample | Bone marrow specimens,bone marrow stromal cells HS-5, myeloid leukemia cells (HL60) and ADR resistant HL60 cells,myeloid leukemia cells (K562) and ADR resistant K562 cells (K562/ADR) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 and Tspan3 were up-regulated, while miR-193a-3p was down-regulated in ADR resistant AML samples and cells. KCNQ1OT1 knockdown reduced ADR resistance, inhibited proliferation, migration and invasion but promoted apoptosis of ADR resistant AML cells, miR-193a-3p inhibition reversed these effects. MiR-193a-3p was a target of KCNQ1OT1 and combined with Tspan3 3' untranslated region (3' UTR). |
| Pubmed ID | 31837329 |
| Year | 2020 |
| Title | LncRNA KCNQ1OT1 Contributes to the Progression and Chemoresistance in Acute Myeloid Leukemia by Modulating Tspan3 Through Suppressing miR-193a-3p |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |