Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | NA |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Dual luciferase reporter gene assay |
| Sample | breast cancer tissues, cell lines (SK-BR-3, BT-20, MX-1, MCF7, HEK293T, Hs 578Bst) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 was found to be remarkably highly expressed in BRCA tissues and cells. KCNQ1OT1 modulated CCNE2 through sponging miR-145 in BRCA. The Kaplan-Meier curve indicated that higher expression levels of KCNQ1OT1 corresponded to poorer patient prognoses. MiR-145 and siRNA-C1 inhibited cell proliferation and metastasis, while promoting cell apoptosis and cell cycle arrest at the G2 stage. |
| Pubmed ID | 30157476 |
| Year | 2018 |
| Title | The Dysregulated Expression of KCNQ1OT1 and Its Interaction with Downstream Factors miR-145/CCNE2 in Breast Cancer Cells. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |