Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p16AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | Retinoblastoma Y79 cells (ATCC, Catalogue No: HTB-18,Manassas, VA),The retinoblastoma and adjacent noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | ANRIL expression was highly expressed in human retinoblastoma tissue as relative to the adjacent noncancerous tissues. ANRIL suppression inhibited Y79 cells viability, migration, invasion, while promoted apoptosis.ANRIL negatively regulated miR-99a by binding to miR-99a. Silence of miR-99a reversed the ANRIL-knockdown effects on Y79 cells.miR-99a overexpression suppressed Y79 cell viability, migration, invasion, and enhanced apoptosis through downregulating c-Myc.miR-99a inhibited JAK/STAT and PI3K/AKT pathways. |
| Pubmed ID | 31184221 |
| Year | 2019 |
| Title | Silence of lncRNA ANRIL Represses Cell Growth and Promotes Apoptosis in Retinoblastoma Cells Through Regulating miR-99a and c-Myc |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |