Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | melanoma tissues, cell lines (HACAT, A375, A875 and MuM-2C) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 expression is up-regulated in melanoma tissues and cells.KCNQ1OT1 promoted cell proliferation and metastasis in melanoma.By directly bindin to miR-153,KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. |
| Pubmed ID | 29667930 |
| Year | 2018 |
| Title | KCNQ1OT1 promotes melanoma growth and metastasis. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |