Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, RNA-FISH etc. |
| Sample | cell lines (HCT116, DLD-1, HCT15, SW480 and HEK293) |
| Expression Pattern | up-regulated |
| Function Description | Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which B-catenin was excessively accumulated in the nucleus. Additionally, overexpression of B-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of B-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that B-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. |
| Pubmed ID | 26868975 |
| Year | 2016 |
| Title | Regulation of functional KCNQ1OT1 lncRNA by B-catenin. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |