Basic Information
| LncRNA/CircRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, KCNQ10T1, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 |
| Ensemble | ENSG00000269821 |
| Refseq | NR_002728 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (Huh-7, SMMC-7721, Hep3B, MHCC97-H and MHCC97-L, LO2, 293T), HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | The ectopic high expression of KCNQ1OT1 was associated with liver cirrhosis,a larger tumor size, an advanced TNM stage,and a worse overall survival and tumor-free survival. KCNQ1OT1 exerted its effects partly by relying on the microRNA-504 (miR-504)mediated regulation of cyclin-dependent kinase 16 (CDK16),in addition to the regulation of the glycogen synthase kinase 3B (GSK3B)/B-catenin/Bcl-2 signaling pathway. The present study revealed the functions and mechanisms of action of lncRNA KCNQ1OT1 regarding its role in promoting the growth of HCC.KCNQ1OT1 may prove to be a potential therapeutic target for human HCC. |
| Pubmed ID | 29532864 |
| Year | 2018 |
| Title | Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504. |
External Links
| Links for KCNQ1OT1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |