Basic Information
| LncRNA/CircRNA Name | KRT7-AS |
| Synonyms | KRT7-AS |
| Region | GRCh38_12:52245048-52247448 |
| Ensemble | ENSG00000257671 |
| Refseq | NR_146274 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RNA-seq, qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | gastric cancer tissues, cell lines (MKN28, KATOIII, AGS, NCI-N87, SNU5) |
| Expression Pattern | up-regulated |
| Function Description | In matched NC-GC tissue pairs obtained from 31 GC patients, KRT7-AS expression was significantly elevated relative to corresponding normal tissue in the majority of GC tissues studied. Levels of KRT7-AS and KRT7 mRNA were positively correlated in GC tissues. Finally, forced overexpression of full-length KRT7-AS or OL KRT7-AS (but not its non-KRT7-OL regions) promoted GC cell proliferation and migration. |
| Pubmed ID | 26876208 |
| Year | 2016 |
| Title | Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. |
External Links
| Links for KRT7-AS | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |