Basic Information
| LncRNA/CircRNA Name | LBX2-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:74502595-74504678 |
| Ensemble | ENSG00000257702 |
| Refseq | NR_024606 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | cell lines (MGC803, BGC823, HGC27, SGC7901,GES1) |
| Expression Pattern | up-regulated |
| Function Description | LBX2-AS1 was up-regulated in GC cell lines. Knockdown of LBX2-AS1 repressed the proliferative, migratory, and invasive abilities of GC cells. Moreover, LBX2-AS1 was transcriptionally activated by NFIC. And LBX2-AS1 could bind with miR-491-5p. |
| Pubmed ID | 32351330 |
| Year | 2020 |
| Title | LBX2-AS1 up-regulated by NFIC boosts cell proliferation, migration and invasion in gastric cancer through targeting miR-491-5p/ZNF703. |
External Links
| Links for LBX2-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |