Basic Information
| LncRNA/CircRNA Name | LCAL6 |
| Synonyms | BLACAT1, LINC00912, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-PCR, Western blot |
| Sample | NSCLC tissues |
| Expression Pattern | up-regulated |
| Function Description | The tumor volume and weight were significantly reduced in the TUG1-silenced group as compared to the control group (p<0.05). However, no significant tumor growth inhibition was found in the LCAL6-silenced group (p>0.05).Expression of both TUG1and LCAL6 was reduced by siRNA treatment. Expression of Ki67 and HOXB7 was significantly suppressed in both the TUG1- and LCAL6-silenced groups compared to the control group (p<0.01). The TUG1-silenced group showed more reduced Ki67 expression than the LCAL6-silenced group (p<0.05). |
| Pubmed ID | 29277771 |
| Year | 2018 |
| Title | Effects of siRNA Silencing of TUG1 and LCAL6 Long Non-coding RNAs on Patient-derived Xenograft of Non-small Cell Lung Cancer. |
External Links
| Links for LCAL6 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |