Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, other |
| Sample | GC tissues and cell lines SGC7901, BGC823, MGC803, MKN28 and MKN45 |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, we assessed the expression levels of the lncRNA ANRIL in GC and found that it was negatively associated with the level of PLZF and that ANRIL indirectly methylated PLZF to suppress its expression via binding with polycomb repressive complex 2.?These results indicated that constitutive ANRIL activation was a possible cause of the lack of PLZF expression in GC cells. |
| Pubmed ID | 30431129 |
| Year | 2019 |
| Title | Tumor Suppressor PLZF Regulated by lncRNA ANRIL Suppresses Proliferation and Epithelial Mesenchymal Transformation of Gastric Cancer Cells |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |