Basic Information
| LncRNA/CircRNA Name | LEF1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108167525-108256836 |
| Ensemble | ENSG00000232021 |
| Refseq | NR_029373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | RT-qPCR, Western blot |
| Sample | retinoblastoma tissues,cell lines (SO-Rb50 and HXO-RB44) |
| Expression Pattern | up-regulated |
| Function Description | silencing of LEF1-AS1 suppressed retinoblastoma cell proliferation, migration, and invasion through regulating the Wnt/?-catenin pathway. |
| Pubmed ID | 31990064 |
| Year | 2020 |
| Title | Long non-coding RNA LEF1-AS1 is involved in the progression of retinoblastoma through regulating the Wnt/?-catenin pathway |
External Links
| Links for LEF1-AS1 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |