Basic Information
| LncRNA/CircRNA Name | LEF1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108167525-108256836 |
| Ensemble | ENSG00000232021 |
| Refseq | NR_029373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | colon cancer samples and matched tumor-adjacent tissue,colon cancer cell lines (COLO320, SW480, SW1417, SW948, T84, HT29 and human HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | EF1-AS1 was upregulated in colon cancer patients and correlated with poor overall survival and recurrent-free survival. Besides, enforced expression of LEF1-AS1 in HT29 and T84 cells promoted migration, invasion, anchorage-independent growth, tumor xenograft formation and lung metastasis, while knockdown of LEF1-AS1 in COLO320 cells suppressed cell migration, invasion, anchorage-independent growth and tumor xenograft formation. |
| Pubmed ID | 32308428 |
| Year | 2020 |
| Title | Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis. |
External Links
| Links for LEF1-AS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |