Basic Information
| LncRNA/CircRNA Name | LEF1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:108167525-108256836 |
| Ensemble | ENSG00000232021 |
| Refseq | NR_029373 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | NSCLC cell lines, H1299 and A549, NSCLC tissues and adjacent nontumor tissues, NSCLC tissues and adjacent nontumor tissues |
| Expression Pattern | up-regulated |
| Function Description | we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. LEF1-AS1 could bind with miR-489 and further negatively regulate miR-489 to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miR-489-SOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC. |
| Pubmed ID | 31386568 |
| Year | 2019 |
| Title | lncRNA LEF1-AS1 Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis |
External Links
| Links for LEF1-AS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |