Basic Information
| LncRNA/CircRNA Name | LIFR-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:38556786-38671216 |
| Ensemble | ENSG00000244968 |
| Refseq | NR_103553 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, Luciferase reporter assay, RNAi |
| Sample | colorectal cancer cell lines (HCT116, HT29 and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | LIFR-AS1 negatively interacted with miR-29a to affect the resistance of CRC to PDT. LIFR-AS1 knockdown attenuated, whereas miR-29a inhibition enhanced the cellular effect of PDT on HCT116 cell proliferation and apoptosis. Furthermore, among the dysregulated mRNAs, TNFAIP3 was confirmed to be a direct target of miR-29a and exerted a similar effect to LIFR-AS1 on the cellular effects of PDT. |
| Pubmed ID | 29807108 |
| Year | 2018 |
| Title | Functional Role of a Long Non-Coding RNA LIFR-AS1/miR-29a/TNFAIP3 Axis in Colorectal Cancer Resistance to Pohotodynamic Therapy |
External Links
| Links for LIFR-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |