Basic Information
| LncRNA/CircRNA Name | LIFR-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:38556786-38671216 |
| Ensemble | ENSG00000244968 |
| Refseq | NR_103553 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | breast cancer tissues and corresponding adjacent tissues ,normal human breast epithelial cell line Hs 578Bst and breast cancer cell lines (MDA-MB-415, MDA-MB-231, MDA-MB-468 and MCF7) |
| Expression Pattern | down-regulated |
| Function Description | LIFR-AS1 was significantly down-regulated in both tissues and cell lines. Furthermore, over-expression of LIFR-AS1 inhibited breast cancer cell proliferation, colony formation, migration and invasion, whereas knockdown of LIFR-AS1 promoted breast cancer cell proliferation, colony formation, migration and invasion.LIFR-AS1 was observed to up-regulate suppressor of fused gene (Sufu) expression by competitively binding to miR-197-3p in breast cancer cells.miR-197-3p inhibitor reversed the promoting effects of LIFR-AS1 knockdown on breast cancer cell proliferation, colony formation, migration and invasion. Additionally, LIFR-AS1 knockdown promoted tumor growth in vivo. |
| Pubmed ID | 31127025 |
| Year | 2019 |
| Title | LIFR-AS1 Modulates Sufu to Inhibit Cell Proliferation and Migration by miR-197-3p in Breast Cancer |
External Links
| Links for LIFR-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |