Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | NA |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | mircoarray, qPCR, Western blot, Luciferase reporter assay |
| Sample | hepatocellular carcinoma tissues, cell lines (SMMC7721, HepG2, SK-hep1, Huh7, L02, 293T) |
| Expression Pattern | down-regulated |
| Function Description | we found that LINC00052 was acted as a tumor suppressor in HCC. luciferase reporter assay revealed that LINC00052 promoted miR-101-3p expression by enhancing its promoter activity. LINC00052 downgulated SOX9 to inhibit HCC cells proliferation and metastasis by interacting with miR-101-3p. |
| Pubmed ID | 30098428 |
| Year | 2018 |
| Title | LINC00052/miR-101-3p Axis Inhibits Cell Proliferation and Metastasis by Targeting SOX9 in Hepatocellular Carcinoma. |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |