Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | NA |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | Breast cancer MCF-7 cells |
| Expression Pattern | down-regulated |
| Function Description | We found several differentially regulated mRNAs and lncRNAs in MCF-7 cell spheroids. We also found significant enrichment of the Wnt/B-catenin death receptor and the cholesterol metabolic processes. Interestingly, we also found an increased concentration of MIF. Further, at 12 and 20 days of 3D culture we found 221 and 1146 dysregulated lncRNAs, respectively; including linc00052 (long intergenic non-protein coding RNA 52), which has been involved in breast cancer. Linc00052 knock-down experiments suggest that it could be a key regulator of cholesterol pathways in breast cancer.linc00052 was of particular interest as it was the most downregulated non-coding RNA at both time points. |
| Pubmed ID | 31301772 |
| Year | 2019 |
| Title | Changes in the transcriptome profile of breast cancer cells grown as spheroids |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |