Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | NA |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | The glioma cell lines U251, U87, T98, SHG44 and U373, The normal human astrocyte 1800 cell line , glioma tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00052 expression was remarkably downregulated in glioma samples compared with that in adjacent samples. Moreover, cell proliferation, invasion, and migration of glioma were inhibited after overexpression of LINC00052 in vitro. Besides, LINC00052 overexpression upregulated mRNA and protein level of KLF6. Besides, the expression of KLF6 in tumor tissues was positively correlated to the expression of LINC00052. |
| Pubmed ID | 31210314 |
| Year | 2019 |
| Title | Long noncoding RNA LINC00052 suppressed the proliferation, migration and invasion of glioma cells by upregulating KLF6 |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |