Basic Information
| LncRNA/CircRNA Name | LINC00052 |
| Synonyms | NA |
| Region | GRCh38_15:87576929-87579866 |
| Ensemble | ENSG00000259527 |
| Refseq | NR_026869 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot |
| Sample | Human cervical cancer cell lines SiHa, HeLa, C4-1 and C-33a and normal cervical epithelium cell line NC104, Cervical cancer tissues and adjacent normal tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC00052 expression level was lower in cervical cancer samples than that in adjacent tissues, which was correlated with disease-free survival time. Moreover, cell proliferation, migration and invasion were inhibited through overexpression of LINC00052 in vitro. The mRNA and protein expression of signal transducers and activators of transcription 3 (STAT3) was downregulated after overexpressing LINC00052 in cervical cancer cells. The STAT3 expression level was negatively correlated with the expression of LINC00052 in cervical cancer tissues. |
| Pubmed ID | 31210293 |
| Year | 2019 |
| Title | LINC00052 inhibits tumor growth, invasion and metastasis by repressing STAT3 in cervical carcinoma |
External Links
| Links for LINC00052 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |