Basic Information
| LncRNA/CircRNA Name | LINC00115 |
| Synonyms | NA |
| Region | GRCh38_1:826206-827522 |
| Ensemble | ENSG00000225880 |
| Refseq | XR_017693 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR , Luciferase reporter assay , Western blot , RIP , RNA-seq , in vitro knockdown etc. |
| Sample | GBM tumors and adjacent tissues ,human GBM cell lines (U87, LN229, LN18, and T98G) ,glioma cell lines |
| Expression Pattern | up-regulated |
| Function Description | LINC00115 is upregulated by TGF-?, acts as a miRNA sponge, and upregulates ZEB1 by competitively binding of miR-200s, thereby enhancing ZEB1 signaling and GSC self-renewal. LINC00115 also promotes ZNF596 transcription by preventing binding of miR-200s to the 5'-UTR of ZNF596, resulting in augmented ZNF596/EZH2/STAT3 signaling and GBM tumor growth.LINC00115 is highly expressed in GBM, and LINC00115 expression or correlated co-expression with ZEB1 or ZNF596 is prognostic for clinical GBM survival. |
| Pubmed ID | 31599491 |
| Year | 2019 |
| Title | TGF-?-activated lncRNA LINC00115 Is a Critical Regulator of Glioma Stem-Like Cell Tumorigenicity |
External Links
| Links for LINC00115 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |