Basic Information
| LncRNA/CircRNA Name | LINC00174 |
| Synonyms | NA |
| Region | GRCh38_7:66376044-66493566 |
| Ensemble | ENSG00000179406 |
| Refseq | NR_026873 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, etc |
| Sample | cell line (hCMEC/D3, ECs,U87MG, and the HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Additionally, linc00174 was also upregulated in GECs from the BTB model in vitro. Knock down of linc00174 increased BTB permeability and reduced the expression of the tight junction-related proteins ZO-1, occludin, and claudin-5. |
| Pubmed ID | 31791014 |
| Year | 2019 |
| Title | Role of linc00174/miR-138-5p (miR-150-5p)/FOSL2 Feedback Loop on Regulating the Blood-Tumor Barrier Permeability |
External Links
| Links for LINC00174 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |