Basic Information
| LncRNA/CircRNA Name | LINC00210 |
| Synonyms | LINC00210, NCRNA00210 |
| Region | GRCh38_1:217892900-217920804 |
| Ensemble | ENSG00000231814 |
| Refseq | NR_048550 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Normal thyroid epithelial cell line Nthy-ori3-1, and various TC cell lines (8505C, XTC-1, FTC-133, TPC-1, and SW579), TC tissues and the adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | Linc00210 expression was upregulated in TC tissues compared to the matched noncancerous tissues. Overexpression of Linc00210 augmented the proliferation, migration, and invasion of TC cells. Mechanistically, Linc00210 served as a sponge for miR-195-5p, thereby counteracting its ability in downregulating the expression of IGF1R and the activation of PI3K/Akt signaling. Moreover, inhibition of Linc00210 suppressed the growth of TC cells in nude mice |
| Pubmed ID | 31240707 |
| Year | 2019 |
| Title | Linc00210 enhances the malignancy of thyroid cancer cells by modulating miR-195-5p/IGF1R/Akt axis |
External Links
| Links for LINC00210 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |