Basic Information
| LncRNA/CircRNA Name | LINC00243 |
| Synonyms | NA |
| Region | GRCh38_6:30798654-30830659 |
| Ensemble | ENSG00000214894 |
| Refseq | NR_130726 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | NSCLC tissues and paired normal tissues ,normal bronchial epithelial cell line BEAS-2B, and NSCLC cell lines (NCI-H1650, SK-MES-1, A549, SPC-A-1, H460 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | LINC00243 expression increased in human NSCLC tissues and associated with poor prognosis of NSCLC patients.LINC00243 knockdown inhibited proliferation and glycolysis of NSCLC cells.LINC00243 acted as a molecular sponge for miR-507, and miR-507 reversed the effect of LINC00243 on promoting proliferation and glycolysis of NSCLC cells.LINC00243 modulated expression of endogenous miR-507-targeted PDK4. LINC00243 promotes proliferation and glycolysis in NSCLC cells by positively regulating PDK4 through sponging miR-507. |
| Pubmed ID | 31595421 |
| Year | 2019 |
| Title | Long Non-Coding RNA LINC00243 Promotes Proliferation and Glycolysis in Non-Small Cell Lung Cancer Cells by Positively Regulating PDK4 Through Sponging miR-507 |
External Links
| Links for LINC00243 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |