Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | NA |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | NSCLC tumor tissues and adjacent normal tissues, cell line (BEAS-2B, HEK293T, A549, H1299, SK-MES-1) |
| Expression Pattern | down-regulated |
| Function Description | Expression of miR-19a was upregulated while KLF2 was downregulated in NSCLC tumors, and there existed a negative linear correlation between miR-19a and LINC00261 or KLF2. Rescue experiments demonstrated that both miR-19a upregulation and KLF2 downregulation could abolish the LINC00261 effect in A549 and H1299 cells. Collectively, the upregulation of LINC00261 suppressed NSCLC cell progression through upregulating miR-19a-mediated KLF2, suggesting LINC00261/miR-19a/KLF2 pathway could contribute to the initiation, development, and prognosis in NSCLC. |
| Pubmed ID | 32305053 |
| Year | 2020 |
| Title | LncRNA-LINC00261 suppresses the progression of NSCLC cells through upregulating miR-19a-mediated Kruppel-like factor 2 (KLF2). |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |