Basic Information
| LncRNA/CircRNA Name | LINC00261 |
| Synonyms | LINC00261, ALIEN, C20orf56, DEANR1, HCCDR1, NCRNA00261, onco-lncRNA-17 |
| Region | GRCh38_20:22547671-22578642 |
| Ensemble | ENSG00000259974 |
| Refseq | NR_001558 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | PDAC tissues |
| Expression Pattern | down-regulated |
| Function Description | The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR.In silico target analysis of miR-802 revealed potential binding sites in the 3??UTR of TCF4, encoding a transcription factor that controls Wnt-signalling genes. Overexpression of miR-802 in MiaPaCa pancreatic cancer cells reduced TCF4 protein levels. |
| Pubmed ID | 25910082 |
| Year | 2015 |
| Title | Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer. |
External Links
| Links for LINC00261 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |