Basic Information
| LncRNA/CircRNA Name | ABHD11-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000225969 |
| Refseq | NR_026690 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | endometrial carcinoma tissues, cell lines (HEC-1B) |
| Expression Pattern | up-regulated |
| Function Description | ABHD11-AS1 was significantly overexpressed in endometrial carcinoma. Overexpression of lncRNA ABHD11-AS1 promoted the proliferation, G1-S progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin D1, CDK1, CDK2, CDK4, Bcl-xl and VEGFA; and down-regulated p16, while ABHD11-AS1 down-regulation has the opposite effect. Overexpression of lncRNA ABHD11-AS1 increased the tumorigenicity and up-regulated cyclin D1 in an in vivo model of endometrial cancer in nude mice. LncRNA ABHD11-AS1 functions as an oncogene to promote cell proliferation and invasion in endometrial carcinoma by positively targeting cyclin D1. |
| Pubmed ID | 29799152 |
| Year | 2018 |
| Title | LncRNA ABHD11-AS1 Promotes the Development of Endometrial Carcinoma by Targeting Cyclin D1 |
External Links
| Links for ABHD11-AS1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |